Nanotechnological approaches for the delivery of macromolecules

Publication Type:

Journal Article

Source:

Journal of Controlled Release, Volume 87, Number 1-3, pp. 81-88 (2003)

ISBN:

0168-3659

DOI Name (links to online publication)

10.1016/S0168-3659(03)00014-2

Keywords:

drug targeting; nanotechnology; liposomes; polymers; polyplexes; lipoplexes; dextran-based hydrogels; recombinant human interleukin-2; ovarian-carcinoma cells; controlled-release; microspheres; protein; system

Abstract:

In this overview, novel approaches are described for the controlled release and/or for the targeted delivery of macromolecules such as proteins and DNA. The building stones of these highly complex systems are (phospho)lipids and/or (biodegradable) polymers. They should be carefully chosen and preparation protocols should be rationally designed to maximize chances for success. (C) 2002 Elsevier Science B.V. All rights reserved.

28/10/2009