Strategies for cytosolic delivery of liposomal macromolecules

Publication Type:

Journal Article

Source:

International Journal of Pharmaceutics, Volume 298, Number 2, pp. 305-309 (2005)

ISBN:

0378-5173

DOI Name (links to online publication)

10.1016/j.ijpharm.2005.02.040

Keywords:

cytosolic delivery; liposomes; endosomal escape; cell-penetrating peptides; photochemical internalization; influenza-virus hemagglutinin; cell-penetrating peptides; photochemical internalization; gene delivery; membrane-fusion; tat-peptide; proteins; tran

Abstract:

Potential approaches to achieve cytosolic delivery of liposomal macromolecules are presented. These approaches include: (1) the co-encapsulation of fusogenic peptides into targeted drug-containing liposomes (2) coupling of the HIV-1-derived cell-penetrating peptide TAT to the surface of liposomes and (3) photochemical internalization, based on photochemically inducible permeabilization of endocytic vesicles. (c) 2005 Elsevier B.V. All rights reserved.

28/10/2009