Reaction to the paper: Interaction of polysorbate 80 with erythropoietin: A case study in protein-surfactant interactions

Publication Type:

Journal Article

Source:

Pharmaceutical Research, Volume 23, Number 3, pp. 641-642 (2006)

ISBN:

0724-8741

DOI Name (links to online publication)

10.1007/s11095-006-9573-5

Keywords:

epoetin; eprex; immunogenicity; micelles; polysorbate 80; immunogenicity

Abstract:

Micelle-associated epoetin is still a possible explanation for the upsurge of pure red blood cell aplasia associated with subcutaneous use of epoetin alpha in patients with chronic renal failure.

28/10/2009