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2014
Halim, L.A., Brinks, V., Jiskoot, W., Romeijn, S., Praditpornsilpa, K., Assawamakin, A., Schellekens, H. , How Bio-questionable are the Different Recombinant Human Erythropoietin Copy Products in Thailand?, Pharmaceutical research, vol. 31, issue 5, pp. 1210-1218. DOI
Torosantucci, R., Brinks, V., Kijanka, G., Halim, L.A., Sauerborn, M., Schellekens, H., Jiskoot, W. , Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin, Journal of pharmaceutical sciences, vol. 103, issue 5, pp. 1367–1374. DOI
2013
Brinks, V., Weinbuch, D., Baker, M., Dean, Y., Stas, P., Kostense, S., Rup, B., Jiskoot, W. , Preclinical Models Used for Immunogenicity Prediction of Therapeutic Proteins, Pharmaceutical research, vol. 30, issue 7, pp. 1719-1728. DOI
Torosantucci, R., Sharov, V.S., van Beers, M., Brinks, V., Schoneich, C., Jiskoot, W. , Identification of Oxidation Sites and Covalent Cross-Links in Metal Catalyzed Oxidized Interferon Beta-1a: Potential Implications for Protein Aggregation and Immunogenicity, Molecular pharmaceutics, vol. 10, issue 6, pp. 2311–2322. DOI
Kijanka, G., Jiskoot, W., Schellekens, H., Brinks, V. , Effect of Treatment Regimen on the Immunogenicity of Human Interferon Beta in Immune Tolerant Mice, Pharm Res, vol. 30, pp. 1553-1560. DOI
Sauerborn, M., van Beers, M.M., Jiskoot, W., Kijanka, G.M., Boon, L., Schellekens, H., Brinks, V. , Antibody Response Against Betaferon(R) in Immune Tolerant Mice: Involvement of Marginal Zone B-cells and CD4+ T-cells and Apparent Lack of Immunological Memory, J Clin Imm, vol. 33, no. 1, pp. 255-63. DOI
2011
Brinks, V., Jiskoot, W., Schellekens, H. , Immunogenicity of therapeutic proteins: the use of animal models, Pharm Res, vol. 28, no. 10, pp. 2379-85. DOI
van Beers, M.M., Sauerborn, M., Gilli, F., Brinks, V., Schellekens, H., Jiskoot, W. , Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice, Pharm Res, vol. 28, no. 10, pp. 2393-402. DOI
Brinks, V., Hawe, A., Basmeleh, A.H.H., Joachin-Rodriguez, L., Haselberg, R., Somsen, G.W., Jiskoot, W., Schellekens, H. , Quality of Original and Biosimilar Epoetin Products, Pharmaceutical Research, vol. 28, no. 2, pp. 386-393. DOI
2010
van Beers, M.M., Sauerborn, M., Gilli, F., Brinks, V., Schellekens, H., Jiskoot, W. , Aggregated Recombinant Human Interferon Beta Induces Antibodies but No Memory in Immune-Tolerant Transgenic Mice, Pharm Res, vol. 27, issue 9, pp. 1812-1824. DOI
van Beers, M.M., Sauerborn, M., Gilli, F., Hermeling, S., Brinks, V., Schellekens, H., Jiskoot, W. , Hybrid transgenic immune tolerant mouse model for assessing the breaking of B cell tolerance by human interferon beta, J Immunol Methods, vol. 352, no. 1-2, pp. 32-7. DOI
Sauerborn, M., Brinks, V., Jiskoot, W., Schellekens, H. , Immunological mechanism underlying the immune response to recombinant human protein therapeutics, Trends Pharmacol Sci, vol. 31, no. 2, pp. 53-9. DOI