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2015
Weinbuch, D., Cheung, J.K., Ketelaars, J., Filipe, V., Hawe, A., den Engelsman, J., Jiskoot, W. , Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations, Pharm Res, vol. 32, issue 7, pp. 2419-2427. DOI
Ahmadi, M., Bryson, C.J., Cloake, E.A., Welch, K., Filipe, V., Romeijn, S., Hawe, A., Jiskoot, W., Baker, M.P., Fogg, M.H. , Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics, Pharm Res, vol. 32, no. 4, pp. 1383-94. DOI
2014
Filipe, V., Que, I, Carpenter, J.F., Lowik, C., Jiskoot, W. , In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice, Pharmaceutical research, vol. 31, no. 1, pp. 216-27. DOI
2013
Filipe, V., Hawe, A., Carpenter, J.F., Jiskoot, W. , Analytical approaches to assess the degradation of therapeutic proteins, Trac-Trends in Analytical Chemistry, vol. 49, pp. 118-125. DOI
Heljo, V.P., Filipe, V., Romeijn, S., Jiskoot, W., Juppo, A.M. , Stability of rituximab in freeze-dried formulations containing trehalose or melibiose under different relative humidity atmospheres, J of Pharm Sci, vol. 102, no. 2, pp. 401-14. DOI
Reshetov, V., Lassalle, H.P., Francois, A., Dumas, D., Hupont, S., Grafe, S., Filipe, V., Jiskoot, W., Guillemin, F., Zorin, V., Bezdetnaya, L. , Photodynamic therapy with conventional and PEGylated liposomal formulations of mTHPC (temoporfin): comparison of treatment efficacy and distribution characteristics in vivo, International Journal of Nanomedicine, vol. 8, pp. 3817-31. DOI
2012
Filipe, V., Jiskoot, W., Basmeleh, A.H., Halim, A., Schellekens, H. , Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice, mAbs, vol. 4, no. 6.
Hawe, A., Romeijn, S., Filipe, V., Jiskoot, W. , Asymmetrical flow field-flow fractionation method for the analysis of submicron protein aggregates, Journal of Pharmaceutical Sciences, vol. 101, no. 11, pp. 4129-39. DOI
Filipe, V., Poole, R., Oladunjoye, O., Braeckmans, K., Jiskoot, W. , Detection and Characterization of Subvisible Aggregates of Monoclonal IgG in Serum, Pharm Res, vol. 29, issue 8, pp. 2202-2212. DOI
Filipe, V., Kukrer, B., Hawe, A., Jiskoot, W. , Transient molten globules and metastable aggregates induced by brief exposure of a monoclonal IgG to low pH, J Pharm Sci, vol. 101, no. 7, pp. 2327-39. DOI
2011
Filipe, V., Poole, R., Kutscher, M., Forier, K., Braeckmans, K., Jiskoot, W. , Fluorescence single particle tracking for the characterization of submicron protein aggregates in biological fluids and complex formulations, Pharm Res, vol. 28, no. 5, pp. 1112-20. DOI
2010
Kukrer, B., Filipe, V., van Duijn, E., Kasper, P.T., Vreeken, R.J., Heck, A.J.R., Jiskoot, W. , Mass Spectrometric Analysis of Intact Human Monoclonal Antibody Aggregates Fractionated by Size-Exclusion Chromatography, Pharmaceutical Research, vol. 27, no. 10, pp. 2197-2204. DOI
Hawe, A., Filipe, V., Jiskoot, W. , Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations, Pharm Res, vol. 27, no. 2, pp. 314-26. DOI