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2015
Weinbuch, D., Cheung, J.K., Ketelaars, J., Filipe, V., Hawe, A., den Engelsman, J., Jiskoot, W. , Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations, Pharm Res, vol. 32, issue 7, pp. 2419-2427. DOI
Ahmadi, M., Bryson, C.J., Cloake, E.A., Welch, K., Filipe, V., Romeijn, S., Hawe, A., Jiskoot, W., Baker, M.P., Fogg, M.H. , Small amounts of sub-visible aggregates enhance the immunogenic potential of monoclonal antibody therapeutics, Pharm Res, vol. 32, no. 4, pp. 1383-94. DOI
2014
2013
Filipe, V., Hawe, A., Carpenter, J.F., Jiskoot, W. , Analytical approaches to assess the degradation of therapeutic proteins, Trac-Trends in Analytical Chemistry, vol. 49, pp. 118-125. DOI
Zolls, S., Weinbuch, D., Wiggenhorn, M., Winter, G., Friess, W., Jiskoot, W., Hawe, A. , Flow Imaging Microscopy for Protein Particle Analysis-A Comparative Evaluation of Four Different Analytical Instruments, The AAPS journal, vol. 15, no. 4, pp. 1200-1211. DOI
Weinbuch, D., Zolls, S., Wiggenhorn, M., Friess, W., Winter, G., Jiskoot, W., Hawe, A. , Micro-flow imaging and resonant mass measurement (archimedes) - complementary methods to quantitatively differentiate protein particles and silicone oil droplets, J Pharmaceutical Sci, vol. 102, issue 7, pp. 2152-2165. DOI
2012
Hawe, A., Romeijn, S., Filipe, V., Jiskoot, W. , Asymmetrical flow field-flow fractionation method for the analysis of submicron protein aggregates, Journal of Pharmaceutical Sciences, vol. 101, no. 11, pp. 4129-39. DOI
Hawe, A., Wiggenhorn, M., van de Weert, M., Garbe, J.H., Mahler, H.C., Jiskoot, W. , Forced degradation of therapeutic proteins, J Pharm Sci, vol. 101, no. 3, pp. 895-913. DOI
Zolls, S., Tantipolphan, R., Wiggenhorn, M., Winter, G., Jiskoot, W., Friess, W., Hawe, A. , Particles in therapeutic protein formulations, Part 1: overview of analytical methods, J Pharm Sci, vol. 101, no. 3, pp. 914-35. DOI
Filipe, V., Kukrer, B., Hawe, A., Jiskoot, W. , Transient molten globules and metastable aggregates induced by brief exposure of a monoclonal IgG to low pH, J Pharm Sci, vol. 101, no. 7, pp. 2327-39. DOI
2011
Hawe, A., Wiggenhorn, M., van de Weert, M., Garbe, J.H., Mahler, H.C., Jiskoot, W. , Forced degradation of therapeutic proteins, J Pharm Sci, vol. 101, issue 3, pp. 895-913. DOI
Avanti, C., Amorij, J.P., Setyaningsih, D., Hawe, A., Jiskoot, W., Visser, J., Kedrov, A., Driessen, A.J., Hinrichs, W.L., Frijlink, H.W. , A New Strategy to Stabilize Oxytocin in Aqueous Solutions: I. The Effects of Divalent Metal Ions and Citrate Buffer, AAPS J, vol. 13, issue 2, pp. 284-290. DOI
Kittipongwarakarn, S., Hawe, A., Tantipolphan, R., Limsuwun, K., Khomvilai, S., Puttipipatkhachorn, S., Jiskoot, W. , New method to produce equine antirabies immunoglobulin F(ab')(2) fragments from crude plasma in high quality and yield, Eur J Pharm Biopharm, vol. 78, issue 2, pp. 189-195. DOI
Maarschalkerweerd, A.V., Wolbink, G.J., Stapel, S.O., Jiskoot, W., Hawe, A. , Comparison of analytical methods to detect instability of etanercept during thermal stress testing, Eur J Pharm Biopharm, vol. 78, issue 2, pp. 213-221. DOI
Brinks, V., Hawe, A., Basmeleh, A.H.H., Joachin-Rodriguez, L., Haselberg, R., Somsen, G.W., Jiskoot, W., Schellekens, H. , Quality of Original and Biosimilar Epoetin Products, Pharmaceutical Research, vol. 28, no. 2, pp. 386-393. DOI
Zolls, S., Tantipolphan, R., Wiggenhorn, M., Winter, G., Jiskoot, W., Friess, W., Hawe, A. , Particles in therapeutic protein formulations, Part 1: Overview of analytical methods, Journal of pharmaceutical sciences. DOI
Hawe, A., Rispens, T., Herron, J.N., Jiskoot, W. , Probing bis-ANS Binding Sites of Different Affinity on Aggregated IgG by Steady-State Fluorescence, Time-Resolved Fluorescence and Isothermal Titration Calorimetry, Journal of Pharmaceutical Sciences, vol. 100, no. 4, pp. 1294-1305. DOI
2010
Hawe, A., Filipe, V., Jiskoot, W. , Fluorescent molecular rotors as dyes to characterize polysorbate-containing IgG formulations, Pharm Res, vol. 27, no. 2, pp. 314-26. DOI
2009
Hawe, A., Kasper, J.C., Friess, W., Jiskoot, W. , Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress, European Journal of Pharmaceutical Sciences, vol. 38, no. 2, pp. 79-87. DOI
Hawe, A., Poole, R., Romeijn, S., Kasper, P., van der Heijden, R., Jiskoot, W. , Towards Heat-stable Oxytocin Formulations: Analysis of Degradation Kinetics and Identification of Degradation Products, Pharmaceutical Research, vol. 26, no. 7, pp. 1679-1688. DOI
2008
Hawe, A., Sutter, M., Jiskoot, W. , Extrinsic fluorescent dyes as tools for protein characterization, Pharmaceutical Research, vol. 25, no. 7, pp. 1487-1499. DOI